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Comparative Study
. 2004 Sep 20;14(18):4623-6.
doi: 10.1016/j.bmcl.2004.07.011.

Spiroquinazolinones as novel, potent, and selective PDE7 inhibitors. Part 1

Edwige Lorthiois  1 , Patrick Bernardelli, Fabrice Vergne, Chrystelle Oliveira, Abdel-Kader Mafroud, Emmanuelle Proust, Lamia Heuze, François Moreau, Moulay Idrissi, Anita Tertre, Bernadette Bertin, Magali Coupe, Roger Wrigglesworth, Arnaud Descours, Patricia Soulard, Patrick Berna
Affiliations
Comparative Study

Spiroquinazolinones as novel, potent, and selective PDE7 inhibitors. Part 1

Edwige Lorthiois et al. Bioorg Med Chem Lett. .

Abstract

The synthesis and SAR studies of spiroquinazolinones as novel PDE7 inhibitors are discussed. The best compounds from the series displayed nanomolar inhibitory affinity and were selective versus other PDE isoenzymes.

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