Comparative Study
doi: 10.1016/j.bmcl.2004.07.010.
Spiroquinazolinones as novel, potent, and selective PDE7 inhibitors. Part 2: Optimization of 5,8-disubstituted derivatives
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- PMID: 15324877
- DOI: 10.1016/j.bmcl.2004.07.010
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Comparative Study
Spiroquinazolinones as novel, potent, and selective PDE7 inhibitors. Part 2: Optimization of 5,8-disubstituted derivatives
Bioorg Med Chem Lett.
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Abstract
The optimization of 5,8-disubstituted spirocyclohexane-quinazolinones into potent, selective, soluble PDE7 inhibitors with acceptable in vivo pharmacokinetic parameters is presented.
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