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Comparative Study
. 2004 Sep 20;14(18):4627-31.
doi: 10.1016/j.bmcl.2004.07.010.

Spiroquinazolinones as novel, potent, and selective PDE7 inhibitors. Part 2: Optimization of 5,8-disubstituted derivatives

Patrick Bernardelli  1 , Edwige Lorthiois, Fabrice Vergne, Chrystelle Oliveira, Abdel-Kader Mafroud, Emmanuelle Proust, Nga Pham, Pierre Ducrot, François Moreau, Moulay Idrissi, Anita Tertre, Bernadette Bertin, Magali Coupe, Eric Chevalier, Arnaud Descours, Françoise Berlioz-Seux, Patrick Berna, Mei Li
Affiliations
Comparative Study

Spiroquinazolinones as novel, potent, and selective PDE7 inhibitors. Part 2: Optimization of 5,8-disubstituted derivatives

Patrick Bernardelli et al. Bioorg Med Chem Lett. .

Abstract

The optimization of 5,8-disubstituted spirocyclohexane-quinazolinones into potent, selective, soluble PDE7 inhibitors with acceptable in vivo pharmacokinetic parameters is presented.

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