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Comparative Study
. 2004 Sep 20;14(18):4647-50.
doi: 10.1016/j.bmcl.2004.06.096.

Synthesis and antibacterial activity of some aryloxy/thioaryloxy oxazolidinone derivatives

Vishal Arora  1 , Manikrao M Salunkhe, Neelima Sinha, Rakesh K Sinha, Sanjay Jain
Affiliations
Comparative Study

Synthesis and antibacterial activity of some aryloxy/thioaryloxy oxazolidinone derivatives

Vishal Arora et al. Bioorg Med Chem Lett. .

Abstract

A series of aryloxy/thioaryloxy oxazolidinone derivatives has been synthesized and tested for in vitro antibacterial activity by MIC determination against a panel of susceptible and resistant Gram-positive and Gram-negative microorganisms, some of which are resistant to methicillin and vancomycin. Compounds 12a, 12b, 14a, and 14b from this series were found to be equipotent or more potent than linezolid in vitro.

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