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Comparative Study
. 2004 Sep 20;14(18):4727-30.
doi: 10.1016/j.bmcl.2004.06.081.

3-Hydroxy-4-arylsulfonyltetrahydropyranyl-3-hydroxamic acids are novel inhibitors of MMP-13 and aggrecanase

Mark C Noe  1 , Sheri L Snow, Lilli A Wolf-Gouveia, Peter G Mitchell, Lori Lopresti-Morrow, Lisa M Reeves, Sue A Yocum, Jennifer L Liras, Marcie Vaughn
Affiliations
Comparative Study

3-Hydroxy-4-arylsulfonyltetrahydropyranyl-3-hydroxamic acids are novel inhibitors of MMP-13 and aggrecanase

Mark C Noe et al. Bioorg Med Chem Lett. .

Abstract

N-Hydroxy-3-hydroxy-4-arylsulfonyltetrahydropyranyl-3-carboxamides were designed as novel inhibitors of MMP-13 and aggrecanase based on known endocyclic hydroxamate inhibitors of matrix metalloproteinases. These compounds offer favorable physicochemical properties and low metabolic clearance. Synthesis and structure-activity relationships are reported.

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