Comparative Study
doi: 10.1016/j.bmcl.2004.06.069.
Synthesis of C8-linked pyrrolo[2,1-c][1,4]benzodiazepine-benzimidazole conjugates with remarkable DNA-binding affinity
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- PMID: 15324909
- DOI: 10.1016/j.bmcl.2004.06.069
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Comparative Study
Synthesis of C8-linked pyrrolo[2,1-c][1,4]benzodiazepine-benzimidazole conjugates with remarkable DNA-binding affinity
Bioorg Med Chem Lett.
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Abstract
Two types of benzimidazoles have been synthesized and linked to DC-81 at C8-position through different alkyl chain spacers. These PBD conjugates have exhibited remarkable DNA-binding affinity, and a representative compound shows promising in vitro anticancer activity.
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