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Comparative Study
. 2004 Sep 20;14(18):4791-4.
doi: 10.1016/j.bmcl.2004.06.069.

Synthesis of C8-linked pyrrolo[2,1-c][1,4]benzodiazepine-benzimidazole conjugates with remarkable DNA-binding affinity

Ahmed Kamal  1 , P Ramulu, O Srinivas, G Ramesh, P Praveen Kumar
Affiliations
Comparative Study

Synthesis of C8-linked pyrrolo[2,1-c][1,4]benzodiazepine-benzimidazole conjugates with remarkable DNA-binding affinity

Ahmed Kamal et al. Bioorg Med Chem Lett. .

Abstract

Two types of benzimidazoles have been synthesized and linked to DC-81 at C8-position through different alkyl chain spacers. These PBD conjugates have exhibited remarkable DNA-binding affinity, and a representative compound shows promising in vitro anticancer activity.

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