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. 2004 Sep 1;126(34):10558-9.
doi: 10.1021/ja046259p.

Highly enantioselective catalytic acyl-pictet-spengler reactions

Mark S Taylor  1 , Eric N Jacobsen
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Highly enantioselective catalytic acyl-pictet-spengler reactions

Mark S Taylor et al. J Am Chem Soc. .

Abstract

The enantioselective cyclization of N-acyliminium ions generated in situ from tryptamine is promoted with high enantioselectivity by a new chiral thiourea catalyst. This represents the first successful system for asymmetric catalysis of the Pictet-Spengler reaction.

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