doi: 10.1021/ja046259p.
Highly enantioselective catalytic acyl-pictet-spengler reactions
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- PMID: 15327311
- DOI: 10.1021/ja046259p
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Highly enantioselective catalytic acyl-pictet-spengler reactions
J Am Chem Soc.
.
Abstract
The enantioselective cyclization of N-acyliminium ions generated in situ from tryptamine is promoted with high enantioselectivity by a new chiral thiourea catalyst. This represents the first successful system for asymmetric catalysis of the Pictet-Spengler reaction.
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