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. 2004 Aug 27;15(4):499-509.
doi: 10.1016/j.molcel.2004.07.009.

Synergy between LRH-1 and beta-catenin induces G1 cyclin-mediated cell proliferation

Oronza A Botrugno  1 , Elisabeth Fayard, Jean-Sébastien Annicotte, Céline Haby, Thomas Brennan, Olivia Wendling, Toshiya Tanaka, Tatsuhiko Kodama, Winston Thomas, Johan Auwerx, Kristina Schoonjans
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Free article

Synergy between LRH-1 and beta-catenin induces G1 cyclin-mediated cell proliferation

Oronza A Botrugno et al. Mol Cell. .
Free article

Abstract

LRH-1 is an orphan nuclear receptor predominantly expressed in tissues of endodermal origin, where it controls development and cholesterol homeostasis. We show here that LRH-1 induces cell proliferation through the concomitant induction of cyclin D1 and E1, an effect that is potentiated by its interaction with beta-catenin. Whereas beta-catenin coactivates LRH-1 on the cyclin E1 promoter, LRH-1 acts as a potent tissue-restricted coactivator of beta-catenin on the cyclin D1 promoter. The implication of LRH-1 in cell proliferation highlights an unanticipated crosstalk between LRH-1 and the beta-catenin/Tcf4 signaling pathway, which is relevant for the renewal of intestinal crypt cells.

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