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. 2004 Sep;48(9):3570-2.
doi: 10.1128/AAC.48.9.3570-3572.2004.

Quinolone-resistant Haemophilus influenzae in a long-term-care facility: nucleotide sequence characterization of alterations in the genes encoding DNA gyrase and DNA topoisomerase IV

Xinying Li  1 , Noriel Mariano, James J Rahal, Carl M Urban, Karl Drlica
Affiliations

Quinolone-resistant Haemophilus influenzae in a long-term-care facility: nucleotide sequence characterization of alterations in the genes encoding DNA gyrase and DNA topoisomerase IV

Xinying Li et al. Antimicrob Agents Chemother. 2004 Sep.

Abstract

Fluoroquinolone-resistant isolates of Haemophilus influenzae, obtained from a long-term care facility, were examined for nucleotide sequence differences in the quinolone-resistance-determining regions of gyrA, gyrB, parC, and parE. Similarities among the resistant isolates, plus multiple differences with susceptible isolates, suggest clonal dissemination involving two resistant subclones.

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