Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2004 Sep;48(9):3586-90.
doi: 10.1128/AAC.48.9.3586-3590.2004.

Genetic and culture-based approaches for detecting macrolide resistance in Chlamydia pneumoniae

Paul F Riska  1 , Andrei Kutlin, Patrick Ajiboye, Arnold Cua, Patricia M Roblin, Margaret R Hammerschlag
Affiliations

Genetic and culture-based approaches for detecting macrolide resistance in Chlamydia pneumoniae

Paul F Riska et al. Antimicrob Agents Chemother. 2004 Sep.

Abstract

Three clinical Chlamydia pneumoniae isolates for which the MIC of azithromycin increased after treatment were investigated for genetic evidence of macrolide resistance. Attempts to induce antibiotic resistance in vitro were made. No genetic mechanism was identified for the phenotypic change in these C. pneumoniae isolates. No macrolide resistance was obtained in vitro.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

References

    1. Arthur, M., C. Molinas, and C. Mabilat. 1993. PCR detection of erm erythromycin resistance genes by using degenerate oligonucleotide primers, p. 534-538. In D. Persing, T. Smith, F. Tenover, and T. J. White (ed.), Diagnostic molecular microbiology: principles and applications. American Society for Microbiology, Washington, D.C.
    1. Beatty, W. L., R. P. Morrison, and G. I. Byrne. 1994. Persistent chlamydiae: from cell culture to a paradigm for chlamydial pathogenesis. Microbiol. Rev. 58:686-699. - PMC - PubMed
    1. Block, S., J. Hedrick, M. R. Hammerschlag, G. H. Cassell, and J. C. Craft. 1995. Mycoplasma pneumoniae and Chlamydia pneumoniae in pediatric community-acquired pneumonia: comparative efficacy and safety of clarithromycin vs. erythromycin ethylsuccinate. Pediatr. Infect. Dis. J. 14:471-477. - PubMed
    1. Boman, J., and M. R. Hammerschlag. 2002. Chlamydia pneumoniae and atherosclerosis: critical assessment of diagnostic methods and relevance to treatment studies. Clin. Microbiol. Rev. 15:1-20. - PMC - PubMed
    1. Canu, A., B. Malbruny, M. Coquemont, T. A. Davies, P. C. Appelbaum, and R. Leclercq. 2002. Diversity of ribosomal mutations conferring resistance to macrolides, clindamycin, streptogramin, and telithromycin in Streptococcus pneumoniae. Antimicrob. Agents Chemother. 46:125-131. - PMC - PubMed

Publication types

MeSH terms

LinkOut - more resources