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. 2004 Sep;48(9):3594-7.
doi: 10.1128/AAC.48.9.3594-3597.2004.

A fusidic acid-resistant epidemic strain of Staphylococcus aureus carries the fusB determinant, whereas fusA mutations are prevalent in other resistant isolates

Alexander J O'Neill  1 , Anders R Larsen, Anne S Henriksen, Ian Chopra
Affiliations

A fusidic acid-resistant epidemic strain of Staphylococcus aureus carries the fusB determinant, whereas fusA mutations are prevalent in other resistant isolates

Alexander J O'Neill et al. Antimicrob Agents Chemother. 2004 Sep.

Abstract

Fusidic acid-resistant epidemic Staphylococcus aureus strains causing impetigo bullosa have been reported in Scandinavia. We show that these strains form part of a European epidemic clonotype that carries the fusB determinant. In contrast, resistance to fusidic acid in a collection of nonepidemic strains resulted primarily from mutations in fusA.

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Figures

FIG. 1.
FIG. 1.
Dendrogram and individual PFGE profiles showing relationships between S. aureus strains employed in this study. The cluster representing the epidemic European clonotype is at the top of the figure. Strains carrying the fusB determinant are indicated by the diamonds.
FIG. 2.
FIG. 2.
Detection of fusB in total DNA from clinical fusidic acid-resistant S. aureus strains. Southern hybridization with EcoRI-digested total DNA derived from six representatives of the epidemic clonotype (CS6 to CS607) and a distinct strain (CS642). Plasmid pUB101 is the positive control.
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References

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