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. 2004 Sep;48(9):3602-5.
doi: 10.1128/AAC.48.9.3602-3605.2004.

Activities of dicationic compounds against Trichomonas vaginalis

Andrea L Crowell  1 , Chad E Stephens, Arvind Kumar, David W Boykin, W Evan Secor
Affiliations

Activities of dicationic compounds against Trichomonas vaginalis

Andrea L Crowell et al. Antimicrob Agents Chemother. 2004 Sep.

Abstract

We evaluated 44 novel cationic compounds for activity against metronidazole-sensitive and -resistant Trichomonas vaginalis isolates. Six compounds in three different structural classes demonstrated 50% inhibitory concentrations as low as 1 microM against both sensitive and resistant isolates, suggesting a mode of action independent of parasite biochemical pathways that confer resistance to 5-nitroimidazoles.

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Figures

FIG. 1.
FIG. 1.
Structures of dicationic compounds evaluated in this study.
See this image and copyright information in PMC

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