Nicorandil: a review of its use in the management of stable angina pectoris, including high-risk patients
- PMID: 15329045
- DOI: 10.2165/00003495-200464170-00012
Nicorandil: a review of its use in the management of stable angina pectoris, including high-risk patients
Abstract
Nicorandil (Adancor, Angicor, Dancor, Nikoril [Europe], Ikorel [Europe and Oceania], Sigmart [Japan, Korea and Taiwan]) is an adenosine triphosphate (ATP)-sensitive potassium (KATP) channel agonist with nitrate-like properties used in the management of stable angina pectoris. With well established monotherapeutic antianginal activity and a beneficial effect (when added to optimal antianginal therapy) on clinical outcomes in high-risk patients with stable angina, twice-daily oral nicorandil is a useful alternative or addition to other antianginal therapy.
Similar articles
-
Nicorandil. A review of its pharmacology and therapeutic efficacy in angina pectoris.Drugs. 1992 Oct;44(4):625-55. doi: 10.2165/00003495-199244040-00008. Drugs. 1992. PMID: 1281076 Review.
-
Nicorandil. An updated review of its use in ischaemic heart disease with emphasis on its cardioprotective effects.Drugs. 2000 Oct;60(4):955-74. doi: 10.2165/00003495-200060040-00007. Drugs. 2000. PMID: 11085202 Review.
-
Nicorandil for angina--an update.Drug Ther Bull. 2003 Nov;41(11):86-8. doi: 10.1136/dtb.2003.411186. Drug Ther Bull. 2003. PMID: 14658416 Review.
-
Effects of mitochondrial ATP-sensitive potassium channel activation (nicorandil) in patients with angina pectoris undergoing elective percutaneous coronary interventions: A meta-analysis of randomized controlled trials.Medicine (Baltimore). 2019 Jan;98(3):e14165. doi: 10.1097/MD.0000000000014165. Medicine (Baltimore). 2019. PMID: 30653160 Free PMC article. Review.
-
Effect of nicorandil on coronary events in patients with stable angina: the Impact Of Nicorandil in Angina (IONA) randomised trial.Lancet. 2002 Apr 13;359(9314):1269-75. doi: 10.1016/S0140-6736(02)08265-X. Lancet. 2002. PMID: 11965271 Clinical Trial.
Cited by
-
Recurrence of Takotsubo cardiomyopathy with coronary slow flow phenomenon.J Cardiol Cases. 2012 Mar 16;5(2):e100-e106. doi: 10.1016/j.jccase.2011.10.003. eCollection 2012 Apr. J Cardiol Cases. 2012. PMID: 30532915 Free PMC article.
-
Use of nicorandil in cardiovascular disease and its optimization.Drugs. 2011 Jun 18;71(9):1105-19. doi: 10.2165/11592300-000000000-00000. Drugs. 2011. PMID: 21711058 Review.
-
Practical compendium of antiarrhythmic drugs: a clinical consensus statement of the European Heart Rhythm Association of the European Society of Cardiology.Europace. 2025 Aug 4;27(8):euaf076. doi: 10.1093/europace/euaf076. Europace. 2025. PMID: 40159403 Free PMC article. Review.
-
Potassium channels: a review of broadening therapeutic possibilities for neurological diseases.J Neurol. 2013 Sep;260(9):2201-11. doi: 10.1007/s00415-012-6727-8. Epub 2012 Nov 11. J Neurol. 2013. PMID: 23142946 Review.
-
Stable angina pectoris: antianginal therapies and future directions.Nat Rev Cardiol. 2011 Aug 30;9(1):40-52. doi: 10.1038/nrcardio.2011.129. Nat Rev Cardiol. 2011. PMID: 21878880 Review.
References
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical