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. 1992 Apr 15;89(8):3414-8.
doi: 10.1073/pnas.89.8.3414.

Dorsal-ventral patterning in Drosophila: DNA binding of snail protein to the single-minded gene

Y Kasai  1 , J R Nambu, P M Lieberman, S T Crews
Affiliations

Dorsal-ventral patterning in Drosophila: DNA binding of snail protein to the single-minded gene

Y Kasai et al. Proc Natl Acad Sci U S A. .

Abstract

The Drosophila snail gene is required for proper mesodermal development. Genetic studies suggest that it functions by repressing adjacent ectodermal gene expression including that of the single-minded (sim) gene. The snail gene encodes a protein with a zinc-finger motif, and here we report that the snail gene product is a sequence-specific DNA binding protein. The snail protein recognizes a 14-base-pair consensus sequence that is found nine times in a 2.8-kilobase sim regulatory region. These results provide evidence for the direct control of sim transcription by snail.

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