Enhanced metabolic efficiency contributes to weight regain after weight loss in obesity-prone rats
- PMID: 15331386
- DOI: 10.1152/ajpregu.00463.2004
Enhanced metabolic efficiency contributes to weight regain after weight loss in obesity-prone rats
Abstract
Metabolic adjustments occur with weight loss that may contribute to a high rate of weight regain. We have previously observed in obesity-prone, obese rats that weight reduction is accompanied by a suppression in resting metabolic rate beyond what would be predicted for the change in metabolic mass. In the present study, we examine if this adjustment in metabolic efficiency is affected by the length of time in weight maintenance and if it contributes to the propensity to regain after weight loss. Twenty-four-hour, nonresting, and resting energy expenditure (REE) were obtained by indirect calorimetry and normalized to metabolic mass estimated by dual-energy X-ray absorptiometry. A 10% loss in body weight in weight-reduced rats was accompanied by a 15% suppression in adjusted REE. This enhancement in metabolic efficiency was not altered with either 8 or 16 wk of weight maintenance, but it did resolve when the forced control of intake was removed and the weight was regained. The rate of weight regain increased with the time in weight maintenance and was exceptionally high early during the relapse period. During this high rate of weight gain, the suppression in REE persists while consumption increases to a level that is higher than when they were obese. In summary, an enhanced metabolic efficiency and an elevated appetite both contribute (60% and 40%, respectively) to a large potential energy imbalance that, when the forcible control of energy intake is relieved, becomes actualized and results in an exceptionally high rate of weight regain.
Comment in
-
The drive to regain is mainly in the brain.Am J Physiol Regul Integr Comp Physiol. 2004 Dec;287(6):R1297-300. doi: 10.1152/ajpregu.00582.2004. Am J Physiol Regul Integr Comp Physiol. 2004. PMID: 15528399 Review. No abstract available.
Similar articles
-
Metabolic adjustments with the development, treatment, and recurrence of obesity in obesity-prone rats.Am J Physiol Regul Integr Comp Physiol. 2004 Aug;287(2):R288-97. doi: 10.1152/ajpregu.00010.2004. Epub 2004 Mar 25. Am J Physiol Regul Integr Comp Physiol. 2004. PMID: 15044180
-
Peripheral metabolic responses to prolonged weight reduction that promote rapid, efficient regain in obesity-prone rats.Am J Physiol Regul Integr Comp Physiol. 2006 Jun;290(6):R1577-88. doi: 10.1152/ajpregu.00810.2005. Epub 2006 Feb 2. Am J Physiol Regul Integr Comp Physiol. 2006. PMID: 16455763
-
Regular exercise attenuates the metabolic drive to regain weight after long-term weight loss.Am J Physiol Regul Integr Comp Physiol. 2009 Sep;297(3):R793-802. doi: 10.1152/ajpregu.00192.2009. Epub 2009 Jul 8. Am J Physiol Regul Integr Comp Physiol. 2009. PMID: 19587114 Free PMC article.
-
Attenuating the Biologic Drive for Weight Regain Following Weight Loss: Must What Goes Down Always Go Back Up?Nutrients. 2017 May 6;9(5):468. doi: 10.3390/nu9050468. Nutrients. 2017. PMID: 28481261 Free PMC article. Review.
-
Influence of altered body weight on energy expenditure.Nutr Rev. 1995 Sep;53(9):265-8. doi: 10.1111/j.1753-4887.1995.tb05484.x. Nutr Rev. 1995. PMID: 8577410 Review.
Cited by
-
A Comparative Study of the Anti-Obesity Effects of Dietary Sea Cucumber Saponins and Energy Restriction in Response to Weight Loss and Weight Regain in Mice.Mar Drugs. 2022 Oct 1;20(10):629. doi: 10.3390/md20100629. Mar Drugs. 2022. PMID: 36286453 Free PMC article.
-
Weight Regain after Metabolic Surgery: Beyond the Surgical Failure.J Clin Med. 2024 Feb 18;13(4):1143. doi: 10.3390/jcm13041143. J Clin Med. 2024. PMID: 38398456 Free PMC article. Review.
-
Proposal of a Mathematical Model to Monitor Body Mass over Time in Subjects on a Diet.Nutrients. 2022 Aug 30;14(17):3575. doi: 10.3390/nu14173575. Nutrients. 2022. PMID: 36079828 Free PMC article.
-
A surprising link between the energetics of ovariectomy-induced weight gain and mammary tumor progression in obese rats.Obesity (Silver Spring). 2010 Apr;18(4):696-703. doi: 10.1038/oby.2009.307. Epub 2009 Oct 1. Obesity (Silver Spring). 2010. PMID: 19798068 Free PMC article.
-
Responses of gut microbiota to diet composition and weight loss in lean and obese mice.Obesity (Silver Spring). 2012 Apr;20(4):738-47. doi: 10.1038/oby.2011.111. Epub 2011 May 19. Obesity (Silver Spring). 2012. PMID: 21593810 Free PMC article.
Publication types
MeSH terms
Grants and funding
LinkOut - more resources
Full Text Sources
Medical