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Comparative Study
. 2004 Sep;7(9):1003-9.
doi: 10.1038/nn1301.

Differentiation of mouse embryonic stem cells into a defined neuronal lineage

Miriam Bibel  1 , Jens Richter, Katrin Schrenk, Kerry Lee Tucker, Volker Staiger, Martin Korte, Magdalena Goetz, Yves-Alain Barde
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Comparative Study

Differentiation of mouse embryonic stem cells into a defined neuronal lineage

Miriam Bibel et al. Nat Neurosci. 2004 Sep.

Abstract

Although it has long been known that cultured embryonic stem cells can generate neurons, the lineage relationships with their immediate precursors remain unclear. We report here that selection of highly proliferative stem cells followed by treatment with retinoic acid generated essentially pure precursors that markers identified as Pax-6-positive radial glial cells. As they do in vivo, these cells went on to generate neurons with remarkably uniform biochemical and electrophysiological characteristics.

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