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. 2004 Sep;57(9):956-9.
doi: 10.1136/jcp.2004.017681.

The predictive value of total serum IgE for a positive allergen specific IgE result

D Sinclair  1 , S A Peters
Affiliations

The predictive value of total serum IgE for a positive allergen specific IgE result

D Sinclair et al. J Clin Pathol. 2004 Sep.

Abstract

Background: Measurement of total serum IgE and allergen specific IgE is often requested to assess possible allergy. As public awareness increases, so do requests for allergy assessment; unless there is a clear "allergen suspect" in the history, several allergen specific IgE requests may be made. This increases the likelihood of detecting borderline increases in allergen specific IgE of uncertain relevance, and has important cost implications for the service.

Aims: To provide an evidence base for this observation.

Methods: In this retrospective observational study, results from 301 patients under 16 years of age from whom blood was taken for "allergy testing" from March 2001 to February 2003 were studied.

Results: Allergen specific IgE testing in children with low total serum IgE concentrations (<10 IU/litre) yielded very few positive results (three of 73 children), except in those being investigated for an acute reaction to a single food; when IgE was 11-20 kU/litre, 13 of 73 children had positive allergen specific IgE; in the 21-40 kU/litre IgE group, 16 of 74 children had positive allergen specific IgE and in the 41-80 kU/litre group, 22 of 81 had positive allergen specific IgE.

Conclusions: Allergen specific IgE testing in children with low IgE concentrations (<10 kU/litre) produces few positive results in patients with non-specific symptoms. Laboratories should perform allergy testing for specific allergens regardless of total IgE concentration only when there are convincing clinical reasons to do so, and should not proceed with this if the total IgE is <10 kU/litre and the presenting symptoms are non-specific.

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Figures

Figure 1
Figure 1
Allergen specific IgE in children with total serum IgE <10 kU/litre.
Figure 2
Figure 2
Allergen specific IgE in children with total serum IgE 11–20 kU/litre. HDM, house dust mite.
Figure 3
Figure 3
Allergen specific IgE in children with total serum IgE 21–40 kU/litre. HDM, house dust mite.
Figure 4
Figure 4
Allergen specific IgE in children with total serum IgE 41–80 kU/litre. HDM, house dust mite.
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References

    1. Edenharter G, Bergmann RL, Bergmann KE, et al. Cord blood-IgE as risk factor and predictor for atopic diseases. Clin Exp Allergy 1998;28:671–8. - PubMed
    1. Kjellman NI. Atopic allergy and serum IgE concentrations in randomly selected children followed up from 8 to 12 years of age. Allergy 1984;39:443–50. - PubMed
    1. Calbi M, Giacchetti L, Coppola A, et al. Basophil count of the newborn is not useful in prediction of allergic diseases. Pediatr Med Chir 1996;18:169–72. - PubMed
    1. Backer V, Ulrik CS, Wendelboe D, et al. Distribution of serum IgE in children and adolescents aged 7 to 16 years in Copenhagen, in relation to factors of importance. Allergy 1992;47:484–9. - PubMed
    1. Bruynzeel PL, Houben LA. Evaluation of total and specific IgE determinations in normal children and children suffering from asthmatic bronchitis with suspected allergic disease. Clin Chim Acta 1981;112:315–23. - PubMed