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Comparative Study
. 2004 Sep 1;56(5):376-8.
doi: 10.1016/j.biopsych.2004.06.017.

No association between the Val66Met polymorphism of the brain-derived neurotrophic factor gene and bipolar disorder in a Japanese population: a multicenter study

Hiroshi Kunugi  1 , Yoshimi Iijima, Masahiko Tatsumi, Mariko Yoshida, Ryota Hashimoto, Tadafumi Kato, Kaoru Sakamoto, Takako Fukunaga, Toshiya Inada, Tatsuyo Suzuki, Nakao Iwata, Norio Ozaki, Kazuo Yamada, Takeo Yoshikawa
Affiliations
Comparative Study

No association between the Val66Met polymorphism of the brain-derived neurotrophic factor gene and bipolar disorder in a Japanese population: a multicenter study

Hiroshi Kunugi et al. Biol Psychiatry. .

Abstract

Background: Two previous studies reported a significant association between a missense polymorphism (Val66Met) in the brain-derived neurotrophic factor (BDNF) gene and bipolar disorder; however, contradictory negative results have also been reported, necessitating further investigation.

Methods: We organized a multicenter study of a relatively large sample of 519 patients with bipolar disorder (according to DSM-IV criteria) and 588 control subjects matched for gender, age, and ethnicity (Japanese). Genotyping was done by polymerase chain reaction-based restriction fragment length polymorphism or direct sequencing.

Results: The genotype distributions and allele frequencies were similar among the patients and control subjects. Even if the possible relationships of the polymorphism with several clinical variables (i.e., bipolar I or II, presence of psychotic features, family history, and age of onset) were examined, no variable was related to the polymorphism.

Conclusions: The Val66Met polymorphism of the BDNF gene is unrelated to the development or clinical features of bipolar disorder, at least in a Japanese population.

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