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Review
. 2004 Oct;53(10):879-92.
doi: 10.1007/s00262-004-0577-x. Epub 2004 Jul 28.

Effective immunotherapy against cancer: a question of overcoming immune suppression and immune escape?

Karl-Johan Malmberg  1
Affiliations
Review

Effective immunotherapy against cancer: a question of overcoming immune suppression and immune escape?

Karl-Johan Malmberg. Cancer Immunol Immunother. 2004 Oct.

Abstract

During the last decade, the breakthroughs in understanding of the molecular mechanisms responsible for immune activation and the advent of recombinant DNA technologies have changed the view on immunotherapy from "a dream scenario" to becoming a clinical reality. It is now clear that both cellular immunity comprising T and NK cells, as well as strategies based on antibodies, can provide strong antitumoral effects, and evidence is emerging that these strategies may also cure patients with previously incurable cancers. However, there are still a number of issues that remain unresolved. Progress in immunotherapy against cancer requires a combination of new, improved clinical protocols and strategies for overcoming mechanisms of immune escape and tumor-induced immune suppression. This review discusses some of the salient issues that still need to be resolved, focusing on the role of oxidative stress and the use of antioxidants to alleviate the immune hyporesponsiveness induced by reactive oxygen species (ROS).

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References

    1. Albina JE, Abate JA, Henry WL., Jr Nitric oxide production is required for murine resident peritoneal macrophages to suppress mitogen-stimulated T cell proliferation. Role of IFN-gamma in the induction of the nitric oxide-synthesizing pathway. J Immunol. 1991;147:144. - PubMed
    1. Allison J, Georgiou HM, Strasser A, Vaux DL. Transgenic expression of CD95 ligand on islet beta cells induces a granulocytic infiltration but does not confer immune privilege upon islet allografts. Proc Natl Acad Sci U S A. 1997;94:3943. doi: 10.1073/pnas.94.8.3943. - DOI - PMC - PubMed
    1. Aoe T, Okamoto Y, Saito T. Activated macrophages induce structural abnormalities of the T cell receptor-CD3 complex. J Exp Med. 1995;181:1881. doi: 10.1084/jem.181.5.1881. - DOI - PMC - PubMed
    1. Arai H, Gordon D, Nabel EG, Nabel GJ. Gene transfer of Fas ligand induces tumor regression in vivo. Proc Natl Acad Sci U S A. 1997;94:13862. doi: 10.1073/pnas.94.25.13862. - DOI - PMC - PubMed
    1. Arista MC, Callopoli A, De Franceschi L, et al. Flow cytometric study of lymphocyte subsets in patients at different stages of colorectal carcinoma. Dis Colon Rectum. 1994;37:S30. - PubMed

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