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. 2004 Sep 8;126(35):10834-5.
doi: 10.1021/ja047543j.

A synthetic DNA walker for molecular transport

Jong-Shik Shin  1 , Niles A Pierce
Affiliations

A synthetic DNA walker for molecular transport

Jong-Shik Shin et al. J Am Chem Soc. .

Abstract

Inspired by kinesin movement along a microtubule, we demonstrate a processive bipedal DNA walker. Powered by externally controlled DNA fuel strands, the walker locomotes with a 5 nm stride by advancing the trailing foot to the lead at each step. Real-time monitoring of specific bidirectional walker movement is achieved via multiplexed fluorescence quenching.

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