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Review
. 2004 Sep 3;118(5):532-4.
doi: 10.1016/j.cell.2004.08.022.

Sculpting heart valves with NFATc and VEGF

Diether Lambrechts  1 , Peter Carmeliet
Affiliations
Free article
Review

Sculpting heart valves with NFATc and VEGF

Diether Lambrechts et al. Cell. .
Free article

Abstract

Heart valves are of vital importance for our moment-to-moment existence, but how they form remains a mystery. In this issue of Cell, Chang et al. reveal a novel role for calcineurin, NFATs, and VEGF in valve formation. Dynamic changes in NFAT/VEGF expression in regional myocardial and endocardial fields and developmental windows orchestrate this complex process.

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