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Review
. 2004 Sep 3;118(5):539-44.
doi: 10.1016/j.cell.2004.08.023.

The lingering enigma of the allelic exclusion mechanism

Raul Mostoslavsky  1 , Frederick W Alt, Klaus Rajewsky
Affiliations
Free article
Review

The lingering enigma of the allelic exclusion mechanism

Raul Mostoslavsky et al. Cell. .
Free article

Abstract

B lymphocytes produce diverse antibody specificities by "randomly" assembling antibody genes from germline segments. Yet, though each B lymphocyte has multiple allelic loci for the different antibody chains, each clonally derived mature B lymphocyte expresses a single species of antibody with a unique specificity via a process termed allelic exclusion. Despite some progress, the precise mechanism of allelic exclusion remains an enigma.

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