Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2004 Sep 7;101(36):13101-2.
doi: 10.1073/pnas.0404970101. Epub 2004 Aug 30.

Cycling antibiotics may not be good for your health

Bruce R Levin  1 , Marc J M Bonten
Affiliations
Comment

Cycling antibiotics may not be good for your health

Bruce R Levin et al. Proc Natl Acad Sci U S A. .
No abstract available

PubMed Disclaimer

Figures

Fig. 1.
Fig. 1.
Simulation results with a three-antibiotic–three-resistant states extension of the model in figure 1 of Bergstrom et al. (19). (a) Changes in the frequencies of the different patient states with antibiotic cycling every 90 days: β = 1, c = 0, γ = 0.03, m = 0.07, m1 = m2 = m3 = 0.033333, τ1 + τ2 + τ3 = 0.5, μ = 0.10, σ = 0.25, and α = 0.80. R1, resistant to antibiotic 1; etc. (b) Fraction of patients carrying resistant bacteria: cycling (α = 0.80) solid line and mixing (α = 0) broken line; parameters as in a. (c) Fraction of patients carrying resistant bacteria with cycling (α = 0.80) and mixing (α = 0) with reduced rates of input of patients carrying resistant bacteria m1 = m2 = m3 = 0.01 and improved infection control, β = 0.50. The rest of the parameters are the same as those in a. Copies of the Berkeley madonna program used for this simulation can be obtained from www.eclf.net.
See this image and copyright information in PMC

Comment on

References

    1. Anonymous (1999) Morbid. Mortal. Wkly. Rep. 48, 707–710. - PubMed
    1. Vandenesch, F., Naimi, T., Enright, M. C., Lina, G., Nimmo, G. R., Heffernan, H., Liassine, N., Bes, M., Greenland, T., Reverdy, M. E. & Etienne, J. (2003) Emerg. Infect. Dis. 9, 978–984. - PMC - PubMed
    1. Levy, S. B. (2002) The Antibiotic Paradox: How the Misuse of Antibiotics Destroys Their Curative Powers (Perseus, Cambridge, MA).
    1. Shlaes, D. M., Projan, S. J. & Edwards, J. E. (2004) ASM News 70, 275–281.
    1. Bush, K. (2004) ASM News 70, 282–287.

Publication types

MeSH terms

Substances