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. 2004 Sep;27(9):1471-5.
doi: 10.1248/bpb.27.1471.

HIV-1 inhibitory compounds from Calophyllum brasiliense leaves

Maira Huerta-Reyes  1 , Maria Del Carmen Basualdo, Fumiko Abe, Manuel Jimenez-Estrada, Carmen Soler, Ricardo Reyes-Chilpa
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Free article

HIV-1 inhibitory compounds from Calophyllum brasiliense leaves

Maira Huerta-Reyes et al. Biol Pharm Bull. 2004 Sep.
Free article

Abstract

The hexane, acetone and methanol extracts of Calophyllum brasiliense leaves were fractionated following a three bioassay guide: high HIV-1 RT inhibition, low cytotoxicity on MT2 cells and high inhibition of HIV-1 IIIb/LAV replication. This led to the isolation of three anti HIV-1 dipyranocoumarins: calanolides A and B and soulattrolide. In contrast, other isolated compounds such as apetalic acid, isoapetalic acid, a structural isomer of isoapetalic acid, friedelin, canophyllol and amentoflavone were devoid of HIV-1 RT inhibitory activity. Calanolide C was also obtained as a natural product and showed moderate inhibitory properties.

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