The knockout mouse project
- PMID: 15340423
- PMCID: PMC2716027
- DOI: 10.1038/ng0904-921
The knockout mouse project
Abstract
Mouse knockout technology provides a powerful means of elucidating gene function in vivo, and a publicly available genome-wide collection of mouse knockouts would be significantly enabling for biomedical discovery. To date, published knockouts exist for only about 10% of mouse genes. Furthermore, many of these are limited in utility because they have not been made or phenotyped in standardized ways, and many are not freely available to researchers. It is time to harness new technologies and efficiencies of production to mount a high-throughput international effort to produce and phenotype knockouts for all mouse genes, and place these resources into the public domain.
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Comment in
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A note of caution on the Knockout Mouse Project.Nat Genet. 2004 Nov;36(11):1132. doi: 10.1038/ng1104-1132. Nat Genet. 2004. PMID: 15514659 No abstract available.
References
-
- International Human Genome Sequencing Consortium Nature. 2001;409:860–921. - PubMed
-
- Venter JC, et al. Science. 2001;291:1304–1351. - PubMed
-
- Mouse Genome Sequencing Consortium Nature. 2002;420:520–562. - PubMed
-
- Bultman SJ, Michaud EJ, Woychik RP. Cell. 1992;71:1195–1204. - PubMed
-
- D’Arcangelo G, et al. Nature. 1995;374:719–723. - PubMed
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