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Comment
. 2004 Sep;36(9):937-8.
doi: 10.1038/ng0904-937.

From mRNA to tumor suppressor

Dan Mercola, John Welsh
Comment

From mRNA to tumor suppressor

Dan Mercola et al. Nat Genet. 2004 Sep.

Abstract

The combination of inhibition of RNA degradation and comparative genomic scanning is a powerful new method for detecting gene disruptions. The utility of the method is well-illustrated by a series of observations linking the ephrin receptor EPHB2 to prostate cancer.

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  • Nonsense-mediated decay microarray analysis identifies mutations of EPHB2 in human prostate cancer.
    Huusko P, Ponciano-Jackson D, Wolf M, Kiefer JA, Azorsa DO, Tuzmen S, Weaver D, Robbins C, Moses T, Allinen M, Hautaniemi S, Chen Y, Elkahloun A, Basik M, Bova GS, Bubendorf L, Lugli A, Sauter G, Schleutker J, Ozcelik H, Elowe S, Pawson T, Trent JM, Carpten JD, Kallioniemi OP, Mousses S. Huusko P, et al. Nat Genet. 2004 Sep;36(9):979-83. doi: 10.1038/ng1408. Epub 2004 Aug 8. Nat Genet. 2004. PMID: 15300251

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