doi: 10.1016/j.jneuroim.2004.06.009.
BDNF mRNA expression in rat hippocampus following contextual learning is blocked by intrahippocampal IL-1beta administration
Affiliations
- PMID: 15342202
- DOI: 10.1016/j.jneuroim.2004.06.009
Item in Clipboard
BDNF mRNA expression in rat hippocampus following contextual learning is blocked by intrahippocampal IL-1beta administration
J Neuroimmunol.
2004 Oct.
Abstract
The present study examined the modulating effects of an intrahippocampal injection of interleukin-1beta (IL-1beta) on brain-derived neurotrophic factor (BDNF) mRNA expression 0.5, 2, 4, and 6 h following contextual fear conditioning, a task known to increase BDNF mRNA, in rats. Contextual fear conditioning produced a time-dependent increase in BDNF mRNA that varied by region of hippocampus. IL-1beta blocked or reduced these increases in BDNF mRNA in the CA1, CA2, and dentate gyrus regions of the hippocampus, but had no effect in cortical regions. These data support the idea that IL-1beta-produced memory deficits may be mediated via BDNF mRNA reductions in hippocampus.
Copyright 2004 Elsevier B.V.
Similar articles
-
Early-life infection leads to altered BDNF and IL-1beta mRNA expression in rat hippocampus following learning in adulthood.Brain Behav Immun. 2008 May;22(4):451-5. doi: 10.1016/j.bbi.2007.10.003. Epub 2007 Nov 7. Brain Behav Immun. 2008. PMID: 17997277
-
Brain-derived neurotrophic factor mRNA downregulation produced by social isolation is blocked by intrahippocampal interleukin-1 receptor antagonist.Neuroscience. 2003;121(4):847-53. doi: 10.1016/s0306-4522(03)00564-5. Neuroscience. 2003. PMID: 14580934
-
Systemic administration of lipopolysaccharide and interleukin-1beta have different effects on memory consolidation.Brain Res Bull. 2005 Sep 30;67(1-2):24-9. doi: 10.1016/j.brainresbull.2005.05.024. Brain Res Bull. 2005. PMID: 16140159
-
Brain-derived neurotrophic factor in amygdala-dependent learning.Neuroscientist. 2005 Aug;11(4):323-33. doi: 10.1177/1073858404272255. Neuroscientist. 2005. PMID: 16061519 Review.
-
Corticosterone effects on BDNF expression in the hippocampus. Implications for memory formation.Stress. 2000 May;3(3):201-8. doi: 10.3109/10253890009001124. Stress. 2000. PMID: 10938581 Review.
Cited by
-
Role of neuroinflammation in the emotional and cognitive alterations displayed by animal models of obesity.Front Neurosci. 2015 Jul 3;9:229. doi: 10.3389/fnins.2015.00229. eCollection 2015. Front Neurosci. 2015. PMID: 26190966 Free PMC article. Review.
-
MDMA administration attenuates hippocampal IL-β immunoreactivity and subsequent stress-enhanced fear learning: An animal model of PTSD.Brain Behav Immun Health. 2022 Oct 29;26:100542. doi: 10.1016/j.bbih.2022.100542. eCollection 2022 Dec. Brain Behav Immun Health. 2022. PMID: 36388136 Free PMC article.
-
The immune system and developmental programming of brain and behavior.Front Neuroendocrinol. 2012 Aug;33(3):267-86. doi: 10.1016/j.yfrne.2012.08.006. Epub 2012 Sep 9. Front Neuroendocrinol. 2012. PMID: 22982535 Free PMC article. Review.
-
Review: microglia of the aged brain: primed to be activated and resistant to regulation.Neuropathol Appl Neurobiol. 2013 Feb;39(1):19-34. doi: 10.1111/j.1365-2990.2012.01306.x. Neuropathol Appl Neurobiol. 2013. PMID: 23039106 Free PMC article. Review.
-
Early-life programming of later-life brain and behavior: a critical role for the immune system.Front Behav Neurosci. 2009 Aug 24;3:14. doi: 10.3389/neuro.08.014.2009. eCollection 2009. Front Behav Neurosci. 2009. PMID: 19738918 Free PMC article.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Medical
Miscellaneous
