Comparative Study
doi: 10.1128/JB.186.18.6332-6334.2004.
Extensive genomic polymorphism within Mycobacterium avium
Affiliations
- PMID: 15342607
- PMCID: PMC515132
- DOI: 10.1128/JB.186.18.6332-6334.2004
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Comparative Study
Extensive genomic polymorphism within Mycobacterium avium
J Bacteriol.
2004 Sep.
Abstract
We have initiated comparative genomic analysis of Mycobacterium avium subspecies by DNA microarray, uncovering 14 large sequence polymorphisms (LSPs) comprising over 700 kb that distinguish M. avium subsp. avium from M. avium subsp. paratuberculosis. Genes predicted to encode metabolic pathways were overrepresented in the LSPs, and analysis revealed a polymorphism within the mycobactin biosynthesis operon that potentially explains the in vitro mycobactin dependence of M. avium subsp. paratuberculosis.
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References
-
- Behr, M. A., M. Semret, A. Poon, and E. Schurr. 2004. Crohn's disease, mycobacteria, and NOD2. Lancet Infect. Dis. 4:136-137. - PubMed
-
- Behr, M. A., M. A. Wilson, W. P. Gill, H. Salamon, G. K. Schoolnik, S. Rane, and P. M. Small. 1999. Comparative genomics of BCG vaccines by whole-genome DNA microarray. Science 284:1520-1523. - PubMed
-
- Brennan, M. J., and G. Delogu. 2002. The PE multigene family: a ‘molecular mantra' for mycobacteria. Trends Microbiol. 10:246-249. - PubMed
-
- Brosch, R., S. V. Gordon, M. Marmiesse, P. Brodin, C. Buchrieser, K. Eiglmeier, T. Garnier, C. Gutierrez, G. Hewinson, K. Kremer, L. M. Parsons, A. S. Pym, S. Samper, D. van Soolingen, and S. T. Cole. 2002. A new evolutionary scenario for the Mycobacterium tuberculosis complex. Proc. Natl. Acad. Sci. USA 99:3684-3689. - PMC - PubMed
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