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. 2004 Sep;145(3):403-5.
doi: 10.1016/j.jpeds.2004.04.048.

Maintaining the nelfinavir trough concentration above 0.8 mg/L improves virologic response in HIV-1-infected children

David M Burger  1 , Alina S Bergshoeff, Ronald De Groot, Diana Gibb, Sarah Walker, Jean-Marc Tréluyer, Richard M W Hoetelmans; PENTA 5 study group
Affiliations

Maintaining the nelfinavir trough concentration above 0.8 mg/L improves virologic response in HIV-1-infected children

David M Burger et al. J Pediatr. 2004 Sep.

Abstract

Differences in virologic response were compared in 32 HIV-infected children with a nelfinavir trough concentration either below (n=7) or above (n=25) 0.8 mg/L. Virologic response at week 48 was observed in 29% of children with subtherapeutic nelfinavir troughs versus 80% in children with therapeutic nelfinavir troughs (P=.02).

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