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Review
. 2004 Sep;4(9):707-17.
doi: 10.1038/nrc1432.

Gene-promoter hypermethylation as a biomarker in lung cancer

Steven A Belinsky  1
Affiliations
Review

Gene-promoter hypermethylation as a biomarker in lung cancer

Steven A Belinsky. Nat Rev Cancer. 2004 Sep.

Abstract

Silencing of genes by aberrant promoter hypermethylation is now recognized as a crucial component in cancer initiation and progression. Highly sensitive assays have been developed to assess gene-promoter methylation in biological fluids. The detection of methylated genes in sputum could lead to the development of a screening test to non-invasively identify early cancer in high-risk people.

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