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Review
. 2004 Sep;112(13):1269-74.
doi: 10.1289/ehp.6950.

The science and practice of carcinogen identification and evaluation

Vincent James Cogliano  1 , Robert A Baan, Kurt Straif, Yann Grosse, Marie Béatrice Secretan, Fatiha El Ghissassi, Paul Kleihues
Affiliations
Review

The science and practice of carcinogen identification and evaluation

Vincent James Cogliano et al. Environ Health Perspect. 2004 Sep.

Abstract

Several national and international health agencies have established programs with the aim of identifying agents and exposures that cause cancer in humans. Carcinogen identification is an activity grounded in the scientific evaluation of the results of human epidemiologic studies, long-term bioassays in experimental animals, and other data relevant to an evaluation of carcinogenicity and its mechanisms. In this commentary, after a brief discussion of the science basis common to the evaluation of carcinogens across different programs, we discuss in more detail the principles and procedures currently used by the IARC Monographs program.

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Figures

Figure 1
Figure 1. The risk assessment paradigm.
Figure 2
Figure 2. The evaluation process used in the IARC Monographs.
Figure 3
Figure 3. The development of drafts at IARC Monograph meetings.
See this image and copyright information in PMC

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