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Review
. 2004 Sep 22;56(11):1649-59.
doi: 10.1016/j.addr.2004.02.014.

Nanoparticle and targeted systems for cancer therapy

Lisa Brannon-Peppas  1 , James O Blanchette
Affiliations
Review

Nanoparticle and targeted systems for cancer therapy

Lisa Brannon-Peppas et al. Adv Drug Deliv Rev. .

Erratum in

  • Adv Drug Deliv Rev. 2009 Apr 28;61(4):364

Abstract

This review explores recent work directed towards more targeted treatment of cancer, whether through more specific anti-cancer agents or through methods of delivery. These areas include delivery by avoiding the reticuloendothelial system, utilizing the enhanced permeability and retention effect and tumor-specific targeting. Treatment opportunities using antibody-targeted therapies are summarized. The ability to treat cancer by targeting delivery through angiogenesis is also discussed and antiangiogenic drugs in clinical trials are presented. Delivery methods that specifically use nanoparticles are also highlighted, including both degradable and nondegradable polymers.

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