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Review
. 2004 Oct;4(5):447-52.
doi: 10.1016/j.coph.2004.07.004.

The current status of, and challenges in, the development of CCR5 inhibitors as therapeutics for HIV-1 infection

Kenji Maeda  1 , Hirotomo Nakata, Hiromi Ogata, Yasuhiro Koh, Toshikazu Miyakawa, Hiroaki Mitsuya
Affiliations
Review

The current status of, and challenges in, the development of CCR5 inhibitors as therapeutics for HIV-1 infection

Kenji Maeda et al. Curr Opin Pharmacol. 2004 Oct.

Abstract

The discovery of CCR5 as a HIV-1 co-receptor unfolded the cryptic and complicated process of HIV-1 cellular entry and has provided more than a few entry steps as possible modalities for effective viral intervention. The proof-of-principle has already been established for the use of entry inhibitors against HIV-1 and there is a cautious optimism that several CCR5 inhibitors might soon be added to our armamentarium for therapy of HIV-1 infection.

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