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. 1992 Jan;3(1):62-4.
doi: 10.1097/00001756-199201000-00016.

Effects of the 5HT1A agonist, 8-OH-DPAT, on operant food intake in non-deprived rats

I S Ebenezer  1
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Effects of the 5HT1A agonist, 8-OH-DPAT, on operant food intake in non-deprived rats

I S Ebenezer. Neuroreport. 1992 Jan.

Abstract

The aim of the present study was to determine whether the hyperphagia produced by systemic administration of 8-OH-DPAT is independent of drug-induced chewing or gnawing behaviour. The effects of 8-OH-DPAT (15.625-500 micrograms kg-1, s.c.) were therefore investigated on operant food intake in non-deprived rats. Low doses (i.e. 15.625-62.5 micrograms kg-1) increased operant food intake. Drug-induced stereotypy disrupted operant responding at the higher doses. The results thus suggest that 8-OH-DPAT-induced hyperphagia is independent of chewing or gnawing behaviour.

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