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Editorial
. 2004 Sep 7;110(10):1180-2.
doi: 10.1161/01.CIR.0000140722.85490.EA.

Targeted therapy to prevent progression of calcific aortic stenosis

Nalini M Rajamannan, Catherine M Otto
Editorial

Targeted therapy to prevent progression of calcific aortic stenosis

Nalini M Rajamannan et al. Circulation. .
No abstract available

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Figures

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Important cellular pathways involved in development of aortic valve calcification, with potential targets for drug therapy outlined in red. ACEI indicates ACE inhibitor.
See this image and copyright information in PMC

Comment in

Comment on

References

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    1. Rajamannan NM, Subramaniam M, Rickard D, et al. Human aortic valve calcification is associated with an osteoblast phenotype. Circulation. 2003;107:2181–2184. - PMC - PubMed
    1. O'Brien KD, Shavelle DM, Caulfield MT, et al. Association of angiotensin-converting enzyme with low-density lipoprotein in aortic valvular lesions and in human plasma. Circulation. 2002;106:2224–2230. - PubMed
    1. Stewart BF, Siscovick D, Lind BK, et al. Clinical factors associated with calcific aortic valve disease. J Am Coll Cardiol. 1997;29:630–634. - PubMed

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