Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 1992 May;268(2):397-9.
doi: 10.1007/BF00318809.

Expression of atrial natriuretic peptide in thymic macrophages after dexamethasone treatment of rats

A M Vollmar  1 , F Colbatzky, R Schulz
Affiliations
Comparative Study

Expression of atrial natriuretic peptide in thymic macrophages after dexamethasone treatment of rats

A M Vollmar et al. Cell Tissue Res. 1992 May.

Abstract

The rat thymus represents a site of synthesis of atrial natriuretic peptide (ANP); the immunosuppressor dexamethasone strikingly increases ANP-expression in this immune organ. The presented data suggest that this increase can be attributed to macrophages. By means of immunohistochemistry and Northern blot analysis these immune cells were found to express ANP-immunoreactivity as well as mRNA coding for ANP. In contrast, macrophages of control thymi displayed only weak ANP-immunoreactivity. Thus, ANP appears to be a constituent of rat thymic macrophages, and its synthesis in the thymus is strongly elevated by acute exposure of the animals to glucocorticoids.

PubMed Disclaimer

References

    1. Endocr Rev. 1989 Nov;10(4):519-36 - PubMed
    1. Endocrinology. 1990 May;126(5):2277-80 - PubMed
    1. Endocr Rev. 1985 Spring;6(2):107-27 - PubMed
    1. Cell Tissue Res. 1982;224(2):291-301 - PubMed
    1. J Steroid Biochem. 1987;27(1-3):201-8 - PubMed

Publication types