Comment
doi: 10.1016/j.immuni.2004.08.002.
Intraepithelial lymphocytes in celiac disease: license to kill revealed
Affiliations
- PMID: 15357941
- DOI: 10.1016/j.immuni.2004.08.002
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Comment
Intraepithelial lymphocytes in celiac disease: license to kill revealed
Immunity.
2004 Sep.
Free article
Abstract
Infiltration of lymphocytes in the small intestinal epithelium is a hallmark of active celiac disease. In this issue of Immunity, two papers uncover mechanisms controlling the cytolytic potential of these cells and provide evidence that lymphocyte killing of enterocytes is an important part of the celiac disease pathogenesis.
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Coordinated induction by IL15 of a TCR-independent NKG2D signaling pathway converts CTL into lymphokine-activated killer cells in celiac disease.Immunity. 2004 Sep;21(3):357-66. doi: 10.1016/j.immuni.2004.06.020. Immunity. 2004. PMID: 15357947
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A direct role for NKG2D/MICA interaction in villous atrophy during celiac disease.Immunity. 2004 Sep;21(3):367-77. doi: 10.1016/j.immuni.2004.06.018. Immunity. 2004. PMID: 15357948
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