doi: 10.1016/j.bmcl.2004.06.034.
Novel bisbenzamidines as potential drug candidates for the treatment of Pneumocystis carinii pneumonia
Affiliations
- PMID: 15357989
- DOI: 10.1016/j.bmcl.2004.06.034
Item in Clipboard
Novel bisbenzamidines as potential drug candidates for the treatment of Pneumocystis carinii pneumonia
Bioorg Med Chem Lett.
.
Abstract
A series of pentamidine congeners has been synthesized and screened for their in vitro activity against Pneumocystis carinii. Among the tested compounds, bisbenzamidines linked by a flexible pentanediamide or hexanediamide chain (7 and 9) emerged as exceptionally potent agents that were more effective and less toxic than pentamidine in the assays described in this study.
Similar articles
-
Bisbenzamidines as antifungal agents. are both amidine functions required to observe an anti-Pneumocystis carinii activity?Molecules. 2010 Jun 11;15(6):4283-93. doi: 10.3390/molecules15064283. Molecules. 2010. PMID: 20657441 Free PMC article.
-
In vitro selection and in vivo efficacy of piperazine- and alkanediamide-linked bisbenzamidines against Pneumocystis pneumonia in mice.Antimicrob Agents Chemother. 2006 Jul;50(7):2337-43. doi: 10.1128/AAC.00126-06. Antimicrob Agents Chemother. 2006. PMID: 16801410 Free PMC article.
-
Highly active anti-Pneumocystis carinii compounds in a library of novel piperazine-linked bisbenzamidines and related compounds.Antimicrob Agents Chemother. 2004 Nov;48(11):4209-16. doi: 10.1128/AAC.48.11.4209-4216.2004. Antimicrob Agents Chemother. 2004. PMID: 15504843 Free PMC article.
-
Pafuramidine for Pneumocystis jiroveci pneumonia in HIV-infected individuals.Expert Rev Anti Infect Ther. 2007 Dec;5(6):921-8. doi: 10.1586/14787210.5.6.921. Expert Rev Anti Infect Ther. 2007. PMID: 18039076 Review.
-
Pneumocystis: unraveling the cloak of obscurity.Trends Microbiol. 2004 May;12(5):243-9. doi: 10.1016/j.tim.2004.03.005. Trends Microbiol. 2004. PMID: 15120144 Review. No abstract available.
Cited by
-
Bisbenzamidines as antifungal agents. are both amidine functions required to observe an anti-Pneumocystis carinii activity?Molecules. 2010 Jun 11;15(6):4283-93. doi: 10.3390/molecules15064283. Molecules. 2010. PMID: 20657441 Free PMC article.
-
Structure-Activity Studies with Bis-Amidines That Potentiate Gram-Positive Specific Antibiotics against Gram-Negative Pathogens.ACS Infect Dis. 2021 Dec 10;7(12):3314-3335. doi: 10.1021/acsinfecdis.1c00466. Epub 2021 Nov 12. ACS Infect Dis. 2021. PMID: 34766746 Free PMC article.
-
Pentamidine analogs as inhibitors of [(3)H]MK-801 and [(3)H]ifenprodil binding to rat brain NMDA receptors.Bioorg Med Chem. 2015 Aug 1;23(15):4489-4500. doi: 10.1016/j.bmc.2015.06.012. Epub 2015 Jun 14. Bioorg Med Chem. 2015. PMID: 26117647 Free PMC article.
-
Alkanediamide-Linked Bisbenzamidines Are Promising Antiparasitic Agents.Pharmaceuticals (Basel). 2016 Apr 19;9(2):20. doi: 10.3390/ph9020020. Pharmaceuticals (Basel). 2016. PMID: 27104545 Free PMC article.
-
Design and synthesis of N¹,N⁵-bis[4-(5-alkyl-1,2,4-oxadiazol-3-yl)phenyl]glutaramides as potential antifungal prodrugs.Molecules. 2013 Sep 12;18(9):11250-63. doi: 10.3390/molecules180911250. Molecules. 2013. PMID: 24036514 Free PMC article.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
