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Review
. 2004 Aug;21(8):1362-73.
doi: 10.1023/b:pham.0000036909.41843.18.

Effects of the chemical structure and the surface properties of polymeric biomaterials on their biocompatibility

You-Xiong Wang  1 , John L Robertson, William B Spillman Jr, Richard O Claus
Affiliations
Review

Effects of the chemical structure and the surface properties of polymeric biomaterials on their biocompatibility

You-Xiong Wang et al. Pharm Res. 2004 Aug.

Abstract

Polymeric biomaterials have extensively been used in medicinal applications. However, factors that determine their biocompatibility are still not very clear. This article reviews various effects of the chemical structure and the surface properties of polymeric biomaterials on their biocompatibility, including protein adsorption, cell adhesion, cytotoxicity, blood compatibility, and tissue compatibility. Understanding these aspects of biocompatibility is important to the improvement of the biocompatibility of existing polymers and the design of new biocompatible polymers.

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