Out-foxing fate; molecular switches create neuronal diversity in the retina
- PMID: 15363386
- DOI: 10.1016/j.neuron.2004.09.001
Out-foxing fate; molecular switches create neuronal diversity in the retina
Abstract
Progenitor cells in the mammalian retina generate at least 55 distinct kinds of neurons. Two reports in this issue of Neuron reveal two transcription factors (Foxn4 and Bhlhb4) that contribute to the development of this remarkable cellular diversity.
Comment on
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The transcription factor Bhlhb4 is required for rod bipolar cell maturation.Neuron. 2004 Sep 16;43(6):779-93. doi: 10.1016/j.neuron.2004.08.032. Neuron. 2004. PMID: 15363390
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Foxn4 controls the genesis of amacrine and horizontal cells by retinal progenitors.Neuron. 2004 Sep 16;43(6):795-807. doi: 10.1016/j.neuron.2004.08.041. Neuron. 2004. PMID: 15363391
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