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Review
. 2004 Oct;16(5):580-9.
doi: 10.1016/j.ceb.2004.07.002.

Eph/ephrin signaling in morphogenesis, neural development and plasticity

Rüdiger Klein  1
Affiliations
Review

Eph/ephrin signaling in morphogenesis, neural development and plasticity

Rüdiger Klein. Curr Opin Cell Biol. 2004 Oct.

Abstract

Ephrins are cell-surface-tethered ligands for Eph receptors, the largest family of receptor tyrosine kinases. During development, the Eph/ephrin cell communication system appears to influence cell behavior such as attraction/repulsion, adhesion/de-adhesion and migration, thereby influencing cell fate, morphogenesis and organogenesis. During adulthood, the Eph/ephrin system continues to play roles in tissue plasticity, for example in shaping dendritic spines during neuronal plasticity. Mechanistically, Eph-ephrin repulsive behavior appears to require ligand-receptor internalization and signaling to Rho GTPases.

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