Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2004 Oct;90(10):1224-8.
doi: 10.1136/hrt.2004.040329.

Carcinoid heart disease: presentation, diagnosis, and management

Affiliations
Review

Carcinoid heart disease: presentation, diagnosis, and management

David J Fox et al. Heart. 2004 Oct.
No abstract available

PubMed Disclaimer

Figures

Figure 1
Figure 1
Biochemical pathway for the synthesis and degradation of serotonin (5-hydroxytryptamine).
Figure 2
Figure 2
(A) Transthoracic echocardiogram in a modified apical four chamber view showing thickened and rigid tricuspid valve (TV) leaflets in an abnormal, fixed open position during systole. Endocardial plaque formation of the subvalvar apparatus is also notable. (B) Colour flow Doppler imaging in the same view shows severe tricuspid regurgitation through a wide regurgitant orifice. MV, mitral valve; RA, right atrium; RV, right ventricle.
Figure 3
Figure 3
Continuous wave Doppler profile of severe tricuspid regurgitation showing the characteristic dagger shaped spectrum with an early peak pressure and rapid decline.

References

    1. Bassan MD, Ahlman H, Wangberg B, et al. Biology and management of the midgut carcinoid syndrome. Am J Surg 1993;165:288–97. - PubMed
    1. Schweizer W , Gloor F, Von Bertrab R, et al. Carcinoid heart disease with left sided lesions. Circulation 1964;29:253–7. - PubMed
    1. Strickman NE, Rossi PA, Massumkhani GA, et al. Carcinoid heart disease: a clinical, pathologic and therapeutic update. Curr Prob Cardiol 1982;6:1–42. - PubMed
    1. Spatz M . Pathogenetic studies of experimentally induced heart lesions and their relation to carcinoid syndrome. Laboratory Investigation 1964;13:288–300. - PubMed
    1. Khan MA, Herzog CA, St Peter JV, et al. The prevalence of cardiac valvular insufficiency assessed by transthoracic echocardiography in obese patients treated with appetite suppression drugs. N Engl J Med 1998;339:713–18. ▸ Important study demonstrating the toxic effects of increased circulatory 5-HT concentrations caused by appetite suppression drugs, mimicking carcinoid and causing endocardial fibrosis. - PubMed