Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2004 Oct;90(10):1229-34.
doi: 10.1136/hrt.2003.025312.

Aldosterone blockade in cardiovascular disease

Allan D Struthers  1
Affiliations
Review

Aldosterone blockade in cardiovascular disease

Allan D Struthers. Heart. 2004 Oct.
No abstract available

PubMed Disclaimer

Figures

Figure 1
Figure 1
Mechanisms of aldosterone escape with angiotensin converting enzyme inhibitor (ACEI) or angiotensin receptor blocker (ARB) treatment. K, potassium.
Figure 2
Figure 2
Mechanisms whereby aldosterone promotes sudden cardiac death.
See this image and copyright information in PMC

References

    1. Silvestre JS, Robert V, Heymes C, et al. Myocardial production of aldosterone and corticosterone in the rat. Physiological regulation. J Biol Chem 1998;273:4883–91. - PubMed
    1. Takeda Y , Miyamori I, Yoneda T, et al. Regulation of aldosterone synthase in human vascular endothelial cells by angiotensin II and adrenocorticotropin. J Clin Endocrinol Metab 1996;81:2797–800. - PubMed
    1. Rocha R , Chander PN, Khanna K, et al. Mineralocorticoid blockade reduces vascular injury in stroke-prone hypertensive rats. Hypertension 1998;31:451–8. ▸ The first demonstration that aldosterone blockade produces tissue injury protection (in experimental animals). - PubMed
    1. Rajogopalan S , Duquaine D, King S, et al. Mineralocorticoid receptor antagonism in experimental atherosclerosis. Circulation 2002;105:2212–6. - PubMed
    1. Brilla CG, Weber KT. Reactive and reparative myocardial fibrosis in arterial hypertension in the rat. Cardiovasc Res 1992;26:671–7. ▸ The first demonstration that aldosterone promotes myocardial fibrosis in experimental animals. - PubMed

MeSH terms

Substances