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. 2005 Jan;59(1):152-4.
doi: 10.1038/sj.ejcn.1602039.

Malnutrition in adults with cystic fibrosis

X Dray  1 , R Kanaan, T Bienvenu, N Desmazes-Dufeu, D Dusser, P Marteau, D Hubert
Affiliations

Malnutrition in adults with cystic fibrosis

X Dray et al. Eur J Clin Nutr. 2005 Jan.

Abstract

Objective: To determine the prevalence and clinical features of malnutrition and its relationship with the CFTR genotype in a cystic fibrosis (CF) adult population.

Design: Cross-sectional study.

Setting: Department of Pulmonology, Cochin Hospital, Paris, France.

Subjects: 163 CF adults seen between 1997 and 1999.

Results: Mean age was 28.8 y. Mean body mass index (BMI) was 19.1 kg/m2. Malnutrition (BMI<18.5 kg/m2) was seen in 81 patients (49.7%). Its severity was associated with diagnosis of CF before the age of 18 y (P<0.01), FEV1 values below 30% (P<0.01), the yearly decline of FEV1 (P<0.01), pancreatic insufficiency (P<0.01) and gastro-oesophageal reflux (P<0.01). Malnutrition was observed in 58.7% of patients with a severe CFTR genotype but in 28.6% of patients with a mild genotype (P<0.001).

Conclusion: Malnutrition remains frequent in adults with CF except in patients presenting with a mild CFTR genotype (leading to a mild phenotype and to later diagnosis).

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