Bisubstrate inhibitors of the enzyme catechol O-methyltransferase (COMT): efficient inhibition despite the lack of a nitro group
- PMID: 15368579
- DOI: 10.1002/cbic.200400084
Bisubstrate inhibitors of the enzyme catechol O-methyltransferase (COMT): efficient inhibition despite the lack of a nitro group
Similar articles
-
Structure-based drug design of catechol-O-methyltransferase inhibitors for CNS disorders.Br J Clin Pharmacol. 2014 Mar;77(3):410-20. doi: 10.1111/bcp.12169. Br J Clin Pharmacol. 2014. PMID: 23713800 Free PMC article. Review.
-
Molecular recognition at the active site of catechol-O-methyltransferase (COMT): adenine replacements in bisubstrate inhibitors.Chemistry. 2011 May 27;17(23):6369-81. doi: 10.1002/chem.201003648. Epub 2011 Apr 27. Chemistry. 2011. PMID: 21538606
-
Molecular recognition at the active site of catechol-o-methyltransferase: energetically favorable replacement of a water molecule imported by a bisubstrate inhibitor.Angew Chem Int Ed Engl. 2009;48(48):9092-6. doi: 10.1002/anie.200904410. Angew Chem Int Ed Engl. 2009. PMID: 19882607 No abstract available.
-
Crystal structures of rat catechol-O-methyltransferase complexed with coumarine-based inhibitor.Biochem Biophys Res Commun. 2009 Jan 16;378(3):494-7. doi: 10.1016/j.bbrc.2008.11.085. Epub 2008 Dec 3. Biochem Biophys Res Commun. 2009. PMID: 19056347
-
Catechol-O-methyltransferase (COMT): biochemistry, molecular biology, pharmacology, and clinical efficacy of the new selective COMT inhibitors.Pharmacol Rev. 1999 Dec;51(4):593-628. Pharmacol Rev. 1999. PMID: 10581325 Review. No abstract available.
Cited by
-
Structure-based drug design of catechol-O-methyltransferase inhibitors for CNS disorders.Br J Clin Pharmacol. 2014 Mar;77(3):410-20. doi: 10.1111/bcp.12169. Br J Clin Pharmacol. 2014. PMID: 23713800 Free PMC article. Review.
-
Catechol-O-methyltransferase and its inhibitors in Parkinson's disease.CNS Drug Rev. 2007 Fall;13(3):352-79. doi: 10.1111/j.1527-3458.2007.00020.x. CNS Drug Rev. 2007. PMID: 17894650 Free PMC article. Review.
-
Discovery of Small Molecules as Membrane-Bound Catechol-O-methyltransferase Inhibitors with Interest in Parkinson's Disease: Pharmacophore Modeling, Molecular Docking and In Vitro Experimental Validation Studies.Pharmaceuticals (Basel). 2021 Dec 31;15(1):51. doi: 10.3390/ph15010051. Pharmaceuticals (Basel). 2021. PMID: 35056108 Free PMC article.
-
Parallel synthesis of a series of non-functional ATP/NAD analogs with activity against trypanosomatid parasites.Mol Divers. 2010 May;14(2):215-24. doi: 10.1007/s11030-009-9160-x. Epub 2009 May 30. Mol Divers. 2010. PMID: 19484371
-
Targeting Metalloenzymes for Therapeutic Intervention.Chem Rev. 2019 Jan 23;119(2):1323-1455. doi: 10.1021/acs.chemrev.8b00201. Epub 2018 Sep 7. Chem Rev. 2019. PMID: 30192523 Free PMC article. Review.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Chemical Information
Miscellaneous