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. 1992 Feb 11;1129(3):331-4.
doi: 10.1016/0167-4781(92)90512-x.

Cloning and sequencing of a COUP transcription factor gene expressed in Xenopus embryos

P J Matharu  1 , G E Sweeney
Affiliations

Cloning and sequencing of a COUP transcription factor gene expressed in Xenopus embryos

P J Matharu et al. Biochim Biophys Acta. .

Abstract

A cDNA clone encoding COUP transcription factor, a member of the steroid/thyroid receptor superfamily, has been isolated from a Xenopus neurula (stage 17 embryo) library. Sequencing of this clone reveals an open reading frame encoding a 397 amino acid protein. The amino acid sequence of Xenopus COUP has been compared with its human and Drosophila homologues showing that there are few similarities within the amino-terminal region, whereas the remainder of the protein, including the putative DNA and ligand binding domains, is very well conserved.

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