Watching the DNA repair ensemble dance
- PMID: 15369665
- DOI: 10.1016/j.cell.2004.09.006
Watching the DNA repair ensemble dance
Abstract
Repair of damaged DNA is a dynamic process that requires careful orchestration of a multitude of enzymes, adaptor proteins, and chromatin constituents. In this issue of Cell, Lisby et al. (2004) provide a visual glimpse into how the diverse signaling and repair machines are organized in space and time around the deadliest genetic lesions--the DNA double-strand breaks.
Comment on
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Choreography of the DNA damage response: spatiotemporal relationships among checkpoint and repair proteins.Cell. 2004 Sep 17;118(6):699-713. doi: 10.1016/j.cell.2004.08.015. Cell. 2004. PMID: 15369670
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