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Review
. 2004 Sep 16;431(7006):338-42.
doi: 10.1038/nature02872.

Revealing the world of RNA interference

Affiliations
Review

Revealing the world of RNA interference

Craig C Mello et al. Nature. .

Abstract

The recent discoveries of RNA interference and related RNA silencing pathways have revolutionized our understanding of gene regulation. RNA interference has been used as a research tool to control the expression of specific genes in numerous experimental organisms and has potential as a therapeutic strategy to reduce the expression of problem genes. At the heart of RNA interference lies a remarkable RNA processing mechanism that is now known to underlie many distinct biological phenomena.

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