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. 1992 Feb;11(2):383-9.
doi: 10.1002/j.1460-2075.1992.tb05066.x.

Cells can use their transferrin receptors for locomotion

M S Bretscher  1
Affiliations

Cells can use their transferrin receptors for locomotion

M S Bretscher. EMBO J. 1992 Feb.

Abstract

Cells of the B lymphoblastoid cell line JY attach to substrata made of antibodies to the transferrin receptor. Many of these attached cells migrate considerable distances. JY cells also attach to an anti-integrin substratum (anti LFA-1), but on this surface they do not migrate. These results suggest that a circulating receptor--the transferrin receptor--can be used for locomotory purposes, whereas LFA-1, which is not endocytosed in these cells, cannot be used for locomotion. This indicates that the endocytotic cycle can drive cell locomotion.

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